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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: IL6ST All Species: 25.45
Human Site: S732 Identified Species: 62.22
UniProt: P40189 Number Species: 9
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P40189 NP_002175.2 918 103537 S732 S S G I G G S S C M S S S R P
Chimpanzee Pan troglodytes XP_001144341 918 103578 S732 S S G I G G S S C M S S S R P
Rhesus Macaque Macaca mulatta XP_001100601 918 103709 S732 S S G I G G S S C M S S S R P
Dog Lupus familis XP_535239 857 96713 S682 S S S R P S I S S S D E N E S
Cat Felis silvestris
Mouse Mus musculus Q00560 917 102434 S730 S S G I G G S S C M S S S R P
Rat Rattus norvegicus P40190 918 102432 S731 S S G I G G S S C M S S S R P
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001505316 793 88837 S618 I G G S S C M S S S R Q S I S
Chicken Gallus gallus NP_990202 918 102477 S737 S S G I G G S S C M S S P R Q
Frog Xenopus laevis NP_001124412 881 98985 P703 Q D I K S M D P L K K N T S E
Zebra Danio Brachydanio rerio NP_001106976 866 98131 S691 D S S I A H W S P D F P V K T
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.4 97.5 85.9 N.A. 77 78.6 N.A. 56.6 59.4 44.9 35.2 N.A. N.A. N.A. N.A. N.A.
Protein Similarity: 100 99.6 98.6 88.8 N.A. 86.7 87.4 N.A. 67 72.2 58.2 51.7 N.A. N.A. N.A. N.A. N.A.
P-Site Identity: 100 100 100 20 N.A. 100 100 N.A. 20 86.6 0 20 N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: 100 100 100 26.6 N.A. 100 100 N.A. 20 86.6 13.3 26.6 N.A. N.A. N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 10 0 0 0 0 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 10 0 0 60 0 0 0 0 0 0 % C
% Asp: 10 10 0 0 0 0 10 0 0 10 10 0 0 0 0 % D
% Glu: 0 0 0 0 0 0 0 0 0 0 0 10 0 10 10 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 10 0 0 0 0 % F
% Gly: 0 10 70 0 60 60 0 0 0 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 10 0 0 0 0 0 0 0 0 0 % H
% Ile: 10 0 10 70 0 0 10 0 0 0 0 0 0 10 0 % I
% Lys: 0 0 0 10 0 0 0 0 0 10 10 0 0 10 0 % K
% Leu: 0 0 0 0 0 0 0 0 10 0 0 0 0 0 0 % L
% Met: 0 0 0 0 0 10 10 0 0 60 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 10 10 0 0 % N
% Pro: 0 0 0 0 10 0 0 10 10 0 0 10 10 0 50 % P
% Gln: 10 0 0 0 0 0 0 0 0 0 0 10 0 0 10 % Q
% Arg: 0 0 0 10 0 0 0 0 0 0 10 0 0 60 0 % R
% Ser: 70 80 20 10 20 10 60 90 20 20 60 60 60 10 20 % S
% Thr: 0 0 0 0 0 0 0 0 0 0 0 0 10 0 10 % T
% Val: 0 0 0 0 0 0 0 0 0 0 0 0 10 0 0 % V
% Trp: 0 0 0 0 0 0 10 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _